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KMID : 1135520150110060311
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Korean Journal of Exercise Rehabilitation
2015 Volume.11 No. 6 p.311 ~ p.319
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Antidepressants modulate glycine action in rat hippocampus
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Chang Hyun-Kyung
Kim Khae-Hawn
Kang Ki-Woon
Kang Yoo-Jin
Kim Tae-Wook
Park Hun-Kyung
Kim Sung-Eun
Kim Chang-Ju
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Abstract
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Antidepressants are drugs that relieve symptoms of depressive disorders. Fluoxetine, tianeptine, and milnacipran are different types of antidepressants, and they have widely been used for relieving of depression symptoms. In the present study, the effects of fluoxetine, tianeptine, and milnacipran on the glycine-induced ion current by nystatin-perforated patch clamp and on the amplitude of field potential in the hippocampal CA1 region by multichannel extracellular recording, MED64, system, were studied. In the present results, fluoxetine, tianeptine, and milnacipran reduced glycine-induced ion current in the hippocampal CA1 neurons in nystatin-perforated patch clamp method. These drugs enhanced the amplitude of the field potential in the hippocampal CA1 region in MED64 system. These results suggest that antidepressants may increase neuronal activity by enhancing field potential through inhibition on glycine-induced ion current.
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KEYWORD
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Antidepressants, Glycine-induced ion current, Field potential, Hippocampus
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